 |
Disclaimer: The information provided below should
not necessarily be interpreted as either conclusive or as a claim of
medicinal benefit.
The anti-microbial efficacy of the Aidance Silver
Oxide has been demonstrated in numerous studies against a broad
spectrum of pathogens (gram-negative and gram-positive bacteria,
viruses and fungi). It has also been subjected to a series of
dermal, oral, ocular and genotoxicity studies. Data strongly
suggests that the Aidance Silver Oxide is non-toxic to humans and
animals at 30,000 PPM, and may be still be non-toxic at higher
levels.
Silver oxide is approved as a safe cosmetic
ingredient internationally; listed as a 'cosmetic biocide' in the
International Dictionary of Cosmetic Ingredients.
In addition, the Aidance Silver Oxide was
extensively reviewed and approved by the EPA (US Environmental
Protection Agency) for use in another germ-killing product
(disinfectant). The EPA had to consider the silver oxide’s ocular
(eye) toxicity, dermal (skin) toxicity and oral (swallowing)
toxicity. The EPA gave the Aidance Silver Oxide its highest safety
rating.
Research organizations that have studied the Aidance
Silver Oxide include Advanced Biosystems, division of Analex Corp.,
Benchmark Analytics, Central Virology Laboratory of the Ministry of
Health--Israel, Exetec Labs SA, Harlan Biotech, Kaplan Hospital
(Israel), MB Research Laboratories, MDS Pharma Services, Parexel
International, Purdue University, Quintiles, Southern Research
Institute, and SRA Technologies.
In-vitro Testing

Bacteria, Viruses and Fungi tested and destroyed by
the Aidance Silver Oxide:
|
|
Microorganism |
Minimum Lethal
Concentration (Parts-Per-Million) |
|
Gram Negative Bacteria |
|
|
Escherichia coli 10231 |
2.50 |
|
|
Escherichia coli 25254 |
2.50 |
|
|
Enterobacter cloacae 13047 |
2.50 |
|
|
Pseudomonas aeruginosa 9027 |
1.25-2.50 |
|
|
Salmonella |
< 2 |
|
Gram Positive Bacteria |
|
|
Bacillus Anthracis (Anthrax) |
< 70.00 |
|
|
Bacillus subtilis 6633 |
5.00 |
|
|
Micrococcus lutena 9341 |
1.25-2.50 |
|
|
Staphylococcus aureus 0927 |
2.50-5.00 |
|
|
Staphylococcus aureus 27543 |
5.00 |
|
|
Staphylococcus epidermidis 12228 |
0.625 |
|
|
Streptococcus agalactiae 27956 |
1.25-5.00 |
|
|
Streptococcus faecium 10541 |
5.00 |
|
|
Streptococcus pyogenes 7958 |
2.50 |
|
|
Streptococcus faecalis |
0.50 |
|
Antibiotic–Resistant (Vancomycin-Resistant)
and Susceptible Bacteria |
|
|
E. coli |
32.00 |
|
|
S. aureus |
32.00 |
|
|
K. pneumoniae |
16.00 |
|
|
S. agalactiae (Group B) |
32.00 |
|
|
P. aeruginosa |
16.00 |
|
|
S. pyogenes |
16.00 |
|
|
E. faecalis ATCC 29212 * |
32.00 |
|
|
E. faecium ATCC 700221 * |
16.00 |
|
Yeast and Mold |
|
|
Candida albicans 16404 |
2.50-5.00 |
|
|
Saccharomyces cerevisiae 2601 |
1.25 |
|
Viruses |
|
|
Herpes Simplex- HSV-1, HSV-2 |
< 96.00 |
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Toxicity Testing

Toxicity studies conducted on the Aidance Silver
Oxide indicated that it is not toxic to eyes, mouth or skin and can
even be ingested in small amounts without harm. This means it should
be safe for normal topical use.
The table below summarizes the results of rigorous
testing to determine the safety of the Aidance Silver Oxide,
assuming its continuous and long-term exposure to human skin, eyes
and mouth. All tests were performed at 30,000 parts-per-million,
approximately five times the amount in any Aidance product. Testing
was performed by an independent laboratory for submission to the US
Environmental Protection Agency (EPA), which resulted in the EPA's
approval of the silver oxide (listed as Tetrasilver tetroxide) as a
disinfectant for use in swimming pools.
Category IV , shown in the below table, is the EPA's
highest safety rating (lowest concern for toxicity). The EPA Fact
Sheet (1996) on our silver oxide states, “Adequate product
chemistry, efficacy, environmental fate, toxicology and ecological
effects data have been submitted and reviewed. The available data
support registration of an end-use product for use as a swimming
pool water disinfectant. Adverse effects to human health are not
anticipated from use of this product.”
|
Acute oral LD50 (Rat) |
LD50 > 5000mg/kg |
Toxicity Category IV |
|
Acute dermal LD50 (Rabbit) |
LD50 > 2000mg/kg |
Toxicity Category III |
|
Primary eye irritation (Rabbit) |
Non-irritant |
Toxicity Category IV |
|
Primary dermal irritation (Rabbit) |
Non-irritant |
Toxicity Category IV |
|
Acute inhalation LD50 |
Waived (In aqueous suspension
does not volatilize) |
NA |
|
Dermal sensitization (Guinea pig) |
Product is not a dermal sensitizer |
NA |
An additional important safety benefit of the Aidance Silver
Oxide is that unlike some silvers, such as colloidal silver and
silver salts, it is not expected to bind with healthy
tissue--the cause of argyria (graying of the skin). This
expectation is based on scanning electron microscopy and
transmission electron microscopy studies (Purdue University,
2004) that suggested covalent (chemically stable) binding of the
Aidance Silver Oxide to pathogens and infected cells, with no
attraction or binding to normal, healthy cells.
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