TECHNOLOGY SAFETY

Disclaimer: The information provided below should not necessarily be interpreted as either conclusive or as a claim of medicinal benefit.

The anti-microbial efficacy of the Aidance Silver Oxide has been demonstrated in numerous studies against a broad spectrum of pathogens (gram-negative and gram-positive bacteria, viruses and fungi). It has also been subjected to a series of dermal, oral, ocular and genotoxicity studies. Data strongly suggests that the Aidance Silver Oxide is non-toxic to humans and animals at 30,000 PPM, and may be still be non-toxic at higher levels.

Silver oxide is approved as a safe cosmetic ingredient internationally; listed as a 'cosmetic biocide' in the International Dictionary of Cosmetic Ingredients.

In addition, the Aidance Silver Oxide was extensively reviewed and approved by the EPA (US Environmental Protection Agency) for use in another germ-killing product (disinfectant). The EPA had to consider the silver oxide’s ocular (eye) toxicity, dermal (skin) toxicity and oral (swallowing) toxicity. The EPA gave the Aidance Silver Oxide its highest safety rating.

Research organizations that have studied the Aidance Silver Oxide include Advanced Biosystems, division of Analex Corp., Benchmark Analytics, Central Virology Laboratory of the Ministry of Health--Israel, Exetec Labs SA, Harlan Biotech, Kaplan Hospital (Israel), MB Research Laboratories, MDS Pharma Services, Parexel International, Purdue University, Quintiles, Southern Research Institute, and SRA Technologies.

In-vitro Testing

Bacteria, Viruses and Fungi tested and destroyed by the Aidance Silver Oxide:

 

Microorganism

Minimum Lethal Concentration
(Parts-Per-Million)

Gram Negative Bacteria

 

Escherichia coli 10231

2.50

 

Escherichia coli 25254

2.50

 

Enterobacter cloacae 13047

2.50

 

Pseudomonas aeruginosa 9027

1.25-2.50

 

Salmonella

< 2

Gram Positive Bacteria

 

Bacillus Anthracis (Anthrax)

< 70.00

 

Bacillus subtilis 6633

5.00

 

Micrococcus lutena 9341

1.25-2.50

 

Staphylococcus aureus 0927

2.50-5.00

 

Staphylococcus aureus 27543

5.00

 

Staphylococcus epidermidis 12228

0.625

 

Streptococcus agalactiae 27956

1.25-5.00

 

Streptococcus faecium 10541

5.00

 

Streptococcus pyogenes 7958

2.50

 

Streptococcus faecalis

0.50

Antibiotic–Resistant (Vancomycin-Resistant) and Susceptible Bacteria

 

E. coli

32.00

 

S. aureus

32.00

 

K. pneumoniae

16.00

 

S. agalactiae (Group B)

32.00

 

P. aeruginosa

16.00

 

S. pyogenes

16.00

 

E. faecalis ATCC 29212 *

32.00

 

E. faecium ATCC 700221 *

16.00

Yeast and Mold

 

Candida albicans 16404

2.50-5.00

 

Saccharomyces cerevisiae 2601

1.25

Viruses

 

Herpes Simplex- HSV-1, HSV-2

< 96.00

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Toxicity Testing

Toxicity studies conducted on the Aidance Silver Oxide indicated that it is not toxic to eyes, mouth or skin and can even be ingested in small amounts without harm. This means it should be safe for normal topical use.

The table below summarizes the results of rigorous testing to determine the safety of the Aidance Silver Oxide, assuming its continuous and long-term exposure to human skin, eyes and mouth. All tests were performed at 30,000 parts-per-million, approximately five times the amount in any Aidance product. Testing was performed by an independent laboratory for submission to the US Environmental Protection Agency (EPA), which resulted in the EPA's approval of the silver oxide (listed as Tetrasilver tetroxide) as a disinfectant for use in swimming pools.

Category IV , shown in the below table, is the EPA's highest safety rating (lowest concern for toxicity). The EPA Fact Sheet (1996) on our silver oxide states, “Adequate product chemistry, efficacy, environmental fate, toxicology and ecological effects data have been submitted and reviewed. The available data support registration of an end-use product for use as a swimming pool water disinfectant. Adverse effects to human health are not anticipated from use of this product.”

Acute oral LD50 (Rat)

LD50 > 5000mg/kg

Toxicity Category IV

Acute dermal LD50 (Rabbit)

LD50 > 2000mg/kg

Toxicity Category III

Primary eye irritation (Rabbit)

Non-irritant

Toxicity Category IV

Primary dermal irritation (Rabbit)

Non-irritant

Toxicity Category IV

Acute inhalation LD50

Waived (In aqueous suspension
does not volatilize)

NA

Dermal sensitization (Guinea pig)

Product is not a dermal sensitizer

NA

An additional important safety benefit of the Aidance Silver Oxide is that unlike some silvers, such as colloidal silver and silver salts, it is not expected to bind with healthy tissue--the cause of argyria (graying of the skin). This expectation is based on scanning electron microscopy and transmission electron microscopy studies (Purdue University, 2004) that suggested covalent (chemically stable) binding of the Aidance Silver Oxide to pathogens and infected cells, with no attraction or binding to normal, healthy cells.

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